Hyaluronic acid, High Purity Hyaluronic Acid(HA), Hyaluronic acid/ CAS: 9004-61-9 price,Hyaluronic Acid for Skin Care CAS NO.9004-61-9

1.USP/EP/BP/FCC/CP

2.GMP/DMF/KOSHER/HALAL/HACCP

3.10 Years Experience

4.Delivery within 5 days

5.OEM ability …

1.USP/EP/BP/FCC/CP
2.GMP/DMF/KOSHER/HALAL/HACCP
3.10 Years Experience
4.Delivery within 5 days
5.OEM ability

1.Introduction of Hyaluronic acid

Hyaluronan (also called hyaluronic acid or hyaluronate or HA) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi, and can be very large, with its molecular weight often reaching the millions. One of the chief components of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors.

The average 70 kg (154 lbs) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day.Hyaluronic acid is also a component of the group A streptococcal extracellular capsule,and is believed to play a role in virulence.

2.Properties of Hyaluronic acid

(1)ACD/LogD (pH 5.5): -11.29  (2)ACD/LogD (pH 7.4): -11.37
(3)ACD/BCF (pH 5.5): 1.00  (4)ACD/BCF (pH 7.4): 1.00
(5)ACD/KOC (pH 5.5): 1.00  (6)ACD/KOC (pH 7.4): 1.00
(7)#H bond acceptors: 25  (8)#H bond donors: 14
(9)#Freely Rotating Bonds: 22  (10)Polar Surface Area: 399.71 ?2
(11)Index of Refraction: 1.666  (12)Molar Refractivity: 161.468 cm3
(13)Molar Volume: 434.034 cm3  (14)Polarizability: 64.011 10-24cm3
(15)Surface Tension: 113.541000366211 dyne/cm  (16)Density: 1.789 g/cm3
(17)Flash Point: 724.531 °C  (18)Enthalpy of Vaporization: 214.825 kJ/mol
(19)Boiling Point: 1274.401 °C at 760 mmHg  (20)Vapour Pressure: 0 mmHg at 25°C 

3.Structure Descriptors of Hyaluronic acid

SMILES:

OC(=O)[C@H]4O[C@H](OC1[C@@H](NC(C)=O)[C@@H](O[C@H](CO)[C@H]1O)O[C@@H]3C(O[C@@H](O[C@H]2[C@H](O)[C@@H](CO)OC(O)[C@@H]2NC(C)=O)[C@H](O)[C@H]3O)C(O)=O)[C@H](O)[C@@H](O)C4O

Std. InChI:

InChI=1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)/t7-,8-,9-,10-,11-,12-,13+,14?,15-,16-,17-,18-,19?,20+,21+,22?,25?,26+,27+,28-/m1/s1

Std. InChIKey:

KIUKXJAPPMFGSW-YXBJCWEESA-N
 

4.Biological synthesis

Hyaluronan is synthesized by a class of integral membrane proteins called hyaluronan synthases, of which vertebrates have three types: HAS1, HAS2, and HAS3. These enzymes lengthen hyaluronan by repeatedly adding glucuronic acid and N-acetylglucosamine to the nascent polysaccharide as it is extruded via ABC-transporter through the cell membrane into the extracellular space.

Hyaluronan synthesis (HAS) has been shown to be inhibited by 4-methylumbelliferone (hymecromone, heparvit), a 7-hydroxy-4-methylcoumarin derivative.This selective inhibition (without inhibiting other glycosaminoglycans) may prove useful in preventing metastasis of malignant tumor cells.

Bacillus Subtilis recently has been genetically modified (GMO) to culture a proprietary formula to yield hyaluronans,in a patented process producing human-grade product.

5.Applications of Hyaluronic acid

Medical applications

Hyaluronan is found in many tissues of the body, such as skin, cartilage, and the vitreous humour. Therefore, it is well suited to biomedical applications targeting these tissues. The first hyaluronan biomedical product, Healon, was developed in the 1970s and 1980s by Pharmacia, and is approved for use in eye surgery (i.e., corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair retinal detachment). Other biomedical companies also produce brands of hyaluronan for opthalmic surgery.

Cosmetic applications

Hyaluronan is a common ingredient in skin-care products.

In 2003, the FDA approved hyaluronan injections for filling soft tissue defects such as facial wrinkles. Restylane is a common trade name for the product. Hyaluronan injections temporarily smooth wrinkles by adding volume under the skin, with effects typically lasting for six months.

Equine applications

Hyaluronan is used in treatment of articular disorders in horses, in particular those in competition or heavy work. It is indicated for carpal and fetlock joint dysfunctions, but not when joint sepsis or fracture are suspected. It is especially used for synovitis associated with equine osteoarthritis. It can be injected directly into an affected joint, or intravenously for less localized disorders. It may cause mild heating of the joint if directly injected, but this does not affect the clinical outcome. Intra-articularly administered medicine is fully metabolized in less than a week.

Note that, according to Canadian regulation, hyaluronan in HY-50 preparation should not be administered to animals to be slaughtered for horse meat. In Europe, however, the same preparation is not considered to have any such effect, and edibility of the horse meat is not affected.

6. Package information
 

20kg/carton

7. Delivery information

Delivery within 5 days