Xylitol GMP supplier 99% CAS NO.87-99-0

1.USP/EP/BP/FCC/CP 2.GMP/DMF/KOSHER/HALAL/HACCP 3.10 Years Experience 4.Delivery within 5 days 5.OEM ability …

1.USP/EP/BP/FCC/CP
2.GMP/DMF/KOSHER/HALAL/HACCP
3.10 Years Experience
4.Delivery within 5 days
5.OEM ability

1.Introduction of Xylitol

Xylitol is a sugar alcohol sweetener used as a sugar substitute. Xylitol has the formula (CHOH)3(CH2OH)2 and is an achiral isomer of pentane-1,2,3,4,5-pentol. Xylitol is roughly as sweet as sucrose with only two-thirds the food energy. Unlike other sweeteners, xylitol is actively beneficial for dental health, reducing caries to a third in regular use, and has been shown to reduce the incidence of ear infections.

Xylitol is found in the fibers of many fruits and vegetables, and can be extracted from various berries, oats, and mushrooms, as well as fibrous material such as corn husks and sugar cane bagasse, and birch.However, industrial production starts from xylan (a hemicellulose) extracted from hardwoods or corncobs, which is hydrolyzed into xylose and catalytically hydrogenated into xylitol.

2.Properties of Xylitol

(1)ACD/LogP: -2.649  (2)# of Rule of 5 Violations: 1 (3)ACD/LogD (pH 5.5): -2.65  (4)ACD/LogD (pH 7.4): -2.65 (5)ACD/BCF (pH 5.5): 1.00  (6)ACD/BCF (pH 7.4): 1.00 (7)ACD/KOC (pH 5.5): 1.00  (8)ACD/KOC (pH 7.4): 1.00 (9)#H bond acceptors: 5  (10)#H bond donors: 5 (11)#Freely Rotating Bonds: 9  (12)Polar Surface Area: 101.15 ?2 (13)Index of Refraction: 1.571  (14)Molar Refractivity: 32.764 cm3 (15)Molar Volume: 99.729 cm3  (16)Polarizability: 12.989 10-24cm3 (17)Surface Tension: 89.6589965820313 dyne/cm  (18)Density: 1.526 g/cm3 (19)Flash Point: 261.85 °C  (20)Enthalpy of Vaporization: 87.759 kJ/mol (21)Boiling Point: 494.527 °C at 760 mmHg  (22)Vapour Pressure: 0 mmHg at 25°C

3.Structure Descriptors of Xylitol

SMILES:

O[C@H](CO)[C@H](O)[C@@H](O)CO

Std. InChI:

InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+

Std. InChIKey:

HEBKCHPVOIAQTA-SCDXWVJYSA-N

4.Production of xylitol

Xylitol was discovered almost simultaneously by German and French chemists in the late 19th century, and was first popularized in Europe as a safe sweetener for people with diabetes that would not affect insulin levels. Its dental significance was researched in Finland in the early 1970s, when scientists at Turku University showed it had significant dental benefits. Those became known as the "Turku sugar studies". Today, using hardwood or maize sources, the largest manufacturer globally is the Danish company Danisco, with several other suppliers from China. Xylitol is produced by hydrogenation of xylose, which converts the sugar (an aldehyde) into a primary alcohol.

5.Medical applications

Dental care

Xylitol is a “tooth-friendly”, nonfermentable sugar alcohol. A review of the scientific literature on the efficacy of xylitol has indicated dental health benefits in caries prevention, showing superior performance to other polyols (polyalcohols). This is because the structure of xylitol contains a tridentate ligand, (H-C-OH)3 that can rearrange with polyvalent cations like Ca++. This interaction allows for Ca++ to be transported through the gut wall barrier and through saliva may remineralize enamel before dental caries form.
 

Diabetes

Possessing approximately 40% less food energy, xylitol is a low-calorie alternative to table sugar. Absorbed more slowly than sugar, it does not contribute to high blood sugar levels or the resulting hyperglycemia caused by insufficient insulin response. This characteristic has also proven beneficial for people suffering from metabolic syndrome, a common disorder that includes insulin resistance, hypertension, hypercholesterolemia, and an increased risk for blood clots.

Osteoporosis

Xylitol also has potential as a treatment for osteoporosis. A group of Finnish researchers has found dietary xylitol prevents weakening of bones in laboratory rats, and actually improves bone density.
 

Ear and upper respiratory infections

Studies have shown xylitol chewing gum can help prevent ear infections (acute otitis media); the act of chewing and swallowing assists with the disposal of earwax and clearing the middle ear, while the presence of xylitol prevents the growth of bacteria in the eustachian tubes (auditory or pharyngotympanic tubes) which connect the nose and ear. When bacteria enter the body, they adhere to the tissues using a variety of sugar complexes. The open nature of xylitol and its ability to form many different sugar-like structures appears to interfere with the ability of many bacteria to adhere. In a double-blind, randomized, controlled trial, saline solutions of xylitol significantly reduced the number of nasal coagulase-negative Staphylococcus bacteria. The researchers attributed the benefits to the increased effectiveness of endogenous (naturally present in the body) antimicrobial factors.In a small clinical trial nasally administered xylitol reduced ear complaints in children previously having chronic complaints, on the order of almost one a month, by more than 92%. The author also reported beneficial effects on asthma with nasal administration.
 

6.Safty information of Xylitol

Xylitol has no known toxicity in humans. In one study, the participants consumed a diet containing a monthly average of 1.5 kg of xylitol with a maximum daily intake of 430 g with no apparent ill effects. Like most sugar alcohols, it has a laxative effect because sugar alcohols are not fully broken down during digestion; albeit one-tenth the strength of sorbitol.[clarification needed] The effect depends upon the individual. In one study of 13 children, four experienced diarrhea when consuming over 65 grams per day. Studies have reported adaptation occurs after several weeks of consumption.

As with other sugar alcohols, with the exception of erythritol, consumption in excess of one's laxation threshold (the amount of sweetener that can be consumed before abdominal discomfort sets in) can result in temporary gastrointestinal side effects, such as bloating, flatulence, and diarrhea. Adaptation, an increase of the laxation threshold, occurs with regular intake. Xylitol has a lower laxation threshold than some sugar alcohols, but is more easily tolerated than others such as mannitol and sorbitol.
 

 7. Package information

25kg/carton

8. Delivery information

Delivery within 5 days